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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

When it’s time to buy a new car, you have 36 brands to choose from. Each automotive brand has something to offer, but not every brand is right for every buyer. Some brands excel at making performance cars, others focus on making family-friendly crossovers or specialize in luxury cars.
项目长度:19个月

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

《傲骨贤妻》(The Good Wife):艾丽西娅(Alicia)的秘密暧昧对象威尔(Will,乔希·查尔斯[Josh Charles]饰)在第五季末死去,CBS频道的这部性感法庭剧似乎要完蛋了,但是第六季却似乎充满了疯狂的能量——艾丽西娅初露头角的政治竞选、新旧公司的权力之争、合伙人卡里(Cary)的棘手法律事务。艾丽西娅不再那么完美,《傲骨贤妻》因此更好看了。
*Writing for a Variety Series: “Last Week Tonight With John Oliver”

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

企业也在其他方面受益。英国国家电网公司的业务分析经理克雷格?罗拉森(Craig Rollason)表示,他通过指导一位Teach Firste人提高了自己的指导技巧。

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 8月房价仅1城下跌 49城涨幅超1%
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

per全部+spect看+ive→全部看到→看法;眼界;透视

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

公司:垃圾处理公司Nation Waste
As a result, 39 percent of the post-90s generation tries to avoid the negative effects of mobile phone use through measures like turning off app notifications, intentionally limiting the frequency of social media interactions and staying away from social media entirely in certain situations.
正当整个时尚界都在为拉格菲尔德哀悼,而除了他的众多继承人,他的爱猫邱佩特可能也会继承他的1.5亿英镑财产的一部份。
卓越雇主排名:25

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Today's and tomorrow's technology sits on top of multiple layers, every one of which is changing and has to inter-operate with others. This makes our gadgets, the internet of things, phones and laptops unstable. And it makes consumers irritated. How many of your apps actually work--and actually make life easier, faster or more fun? I'd expect to see consumer cynicism grow, as delight is overtaken by disappointment. This will put pressure on hardware and software developers to deliver that most boring of qualities: reliability.
菲律宾参议院一委员会就国内发生的法外处决事件举行了听证会,罗纳德?德拉罗萨(Ronald Dela Rosa)在会上表示,自7月1日杜特尔特就任总统后,有712人在警方缉毒行动中被杀,还有1067起死亡正被作为与毒品相关的自告奋勇者杀人案件在调查中。
这项测试的答案没有对错,只要对自己诚实即可。
No.4: The 1st Useful Mechanical Pet

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Over at Huffington Post Mark Gongloff warns: That 'dramatic downgrade of U.S. economic growth in the first quarter revealed the economy's lingering weakness, exposed the folly of Washington's austerity obsession and slapped the Federal Reserve's newfound optimism right in the face.' And with politics deteriorating, it'll get worse.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
From the themed collection: 跨界泛娱乐 玩转家居营销新花样
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

On Turkey, which recently shot down a Russian warplane, Putin said he sees no possibility of overcoming the strained ties with the current Turkish leadership. He said he was shocked to see that Turkey hadn't tried to explain its action but turned to help from NATO instead.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

They are typically designed for students with an average age of 22.
单词extravagant 联想记忆:

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

大约一千八百万人,想要得到一个好的全职工作,但却没能找,这一数字在金融危机过后五年半左右的恢复时间中是高得不寻常的,而且尽管失业时间在半年及以上的人数大幅下降,然而这个数字仍然比2007年7月金融危机发生之前的任何时候都要高。
最终,民主政体或者民主共和国为不同观点乃至不同文化的人们提供了较为和谐地比邻而居的方式。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Against: Although it picked up a best editing prize from the LA Film Critics Association, it was ignored by their New York counterparts. Could its momentum be waning
我冒死地想一想,湖人队在几周后会不会也加入这一阵列呢?照目前这情况,他们必须打出史诗级别烂地比赛才能留住他们的选秀权(给费城的前三保护签位),问题取决于他们是会围绕现有阵容继续缓慢地重建呢还是为了得到下一个巨星扔掉一两个年轻球员呢。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

单词fatigue 联想记忆:
赢家:小牛
谷歌公司一名发言人在上周三时表示,该公司意识到“这是一个错误,哈维尔是无心之失”。
For parents, it is always a struggle to carry their children all day long, especially when they’re getting bigger and heavier.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

The contiguous United States set a temperature record in 2012, a year of scorching heat waves and drought. But, mostly because of the unusual chill in the East, 2014 was only the 34th warmest year on record for the lower 48 states.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
From the themed collection: 建筑垃圾三分钟变身新型建材
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

自从18个月前在亚洲设立业务以来,克拉布一直没有涉足香港房地产市场,因为他表示,价格太高了,可担负性太差。
Consumers in many parts of the world have a preference for buying local which has helped boost the value of local brands.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Best Companies rank: 59

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

For the fourth year in a row, the top five places continue to be dominated by the same five intercontinental EMBAs. Tiemba came top this year not by spectacularly outperforming its rivals but thanks to a strong performance across most indicators. In particular, the alumni have the second highest salary on average ($324,000) behind alumni from the Kellogg/HKUST programme ($408,000). Tiemba is also ranked second for career progression and fourth for work experience.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

报告称,2016年共有6.95亿网民使用手机上网,增长率已经连续第三年超过10%。在所有网民中,用智能手机上网的人占比达到了95.1%,而2015年时这一比例还只有90.1%。
设在日内瓦的国际移民组织星期二公布的数字显示,一百万零五千五百零四名非洲和中东的流动人口,以非常规方式通过陆路和海路进入欧洲大陆,这个数字是2014年的四倍。
“I am proud of my position as a boss, as a person that runs my own company,” Perry told FORBES for our Celebrity 100 cover story this past summer. “I’m an entrepreneur. … I don’t want to shy away from it. I actually want to kind of grab it by its b---s.”
In month-on-month terms, consumer prices fell 0.1 per cent after having risen 0.7 per cent a month earlier.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

从单个大宗商品来看,预计咖啡价格将大幅下跌,目前为1磅1.62美元左右,投资者对阿拉比卡咖啡前景尤为悲观。
platform
当年辛普森(OJ Simpson)杀妻案的审判就说明,再也没什么能比谋杀和名人的组合更能引发公众的集体亢奋了。再加上253号班机爆炸未遂案、几十个恐怖分子、审判律师、公诉人、政客以及911遇难者家属的激动情绪,足够在你面前上演一出长得如同滔滔江水延绵不绝的连续剧。
1.苹果。 品牌喜爱度:57%/排名:32
热门行业

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

巴西对智利比赛的正式票价范围在200美元到25美元之间。最便宜的门票大约占5%的销售额。这些门票只为学生、老年人和政府福利计划的穷人提供。
“他随和、真诚、亲切,”IBM首席执行官罗睿兰(Ginni Rometty)说,并赞赏他“非常本真。这是现代CEO的特质。所见即所得。”

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
From the themed collection: 2017年上半年板材行业七大关键词
Critical Review

The role of biosensors in the detection of emerging infectious diseases

这是充满希望的春天,也是令人绝望的寒冬……

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

'A little bit in shock,' said director Steve McQueen, before shrugging 'Roll, Jordan, roll'-the lyrics to the old gospel song sung in the slavery epic.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Despite the reported success of the Duke and Duchess of Cambridge's official visit to Canada back in September, timekeeping needs to be looked at for future trips.
舒尔茨在星巴克网站上发表了一封信,信中写道:“据我所知,一些公司领导人也对我们保持相对沉默以及我们代表民众要求政府首脑采取行动所产生的影响感到担心。”
乌龙事件澄清之后,《爱乐之城》制片人乔丹?霍罗威茨重新拿回麦克风说 “《月光男孩》获得了最佳影片奖”,而且强调“这不是玩笑”。
Faster progress in work to improve environment, particularly air quality, is what people are desperately hoping for, and is critical to sustainable development. We must adopt well-designed policies, tackle both symptoms and root causes, and take tough steps to make the grade in responding to the people.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

During your early years wasthere anything that inspired or sparked your imagination to start writing theway that you have done so far?
3.贾君鹏,你妈妈喊你回家吃饭。
For Maddie Ziegler, from Pennsylvania, life couldn't be more different.
Ohsumi’s research on autophagy shines a light on ubiquitous diseases such as Parkinson’s and diabetes.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 建筑节能催生绿色建材产品大发展
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

[m?'r?liti]
6. Make a plan.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Global gold production rose to 3,268.7 tonnes in 2017 from 3,263 tonnes a year earlier, according to the WGC. That was the smallest increase since 2008, when gold mined fell more than 2 per cent during the financial crisis.
巴尼汤普森(Barney Thompson)是法律记者
清华大学在计算机科学和工程学两个学科中排名居首。这所中国院校今年取代了麻省理工学院,成为计算机科学最强学府。
As a national exam with more than 1 million test takers every year, the National Postgraduates Entrance Examination is very important for students' academic life, and cheating incidents have been exposed from time to time.
Regional

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

该数据显示10月份下半月北京、天津、上海、深圳、厦门和郑州新建住宅价格出现了环比下滑。
Managers are able to reward their subordinates in unique, personalized ways thanks to the budget they receive from corporate. Two examples of past bonuses: free trail rides at an equestrian stadium and a barbeque with lassoing and horseshow throwing lessons.
另一方面,10月份工业生产者出厂价格(PPI)连续第3个月同比下降5.9%。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

这让11月份的贸易顺差达到446.1亿美元,比10月份减少约44.5亿美元,低于预期。
大型企业PMI为53.1,比上月下降0.7个百分点;中型企业PMI为49.8,回落1.3个百分点,意味着进入轻度收缩。小型企业PMI为49,下降0.4个百分点,意味着收缩加剧。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

动作、探险剧《盗墓笔记》改编自徐磊(笔名南派三叔)的畅销网络小说。它也是中国第一部季播网络剧,预计该小说将被改编为8季,每年播出一季。第一季于2015年6月播出。同名系列小说讲诉了吴邪和小伙伴们在古墓探险的故事,该小说2006年在网上发布后受到了大量粉丝的追捧。因此,大家对改编电视剧期望颇高,不过它却让粉丝们大跌眼镜。尽管首播2分钟后,网络点击量就超过了2千4百万,不过第一季的薄弱情节和粗劣品质很快就被粉丝们炮轰了。剧中的一些台词甚至成了社交媒体上调侃的段子。
答:我的一些作品也来到了美国,自己的作品能够在这里收到喜爱,对此我感到非常的开心和荣幸。
2012年春运期间,12306网站系统约售出110万张车票。去年,该系统售出的车票数量同比增加1100万张。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

施普林格自然集团细胞生物学和生物化学编辑部主任皮特?巴特勒对上海澎湃新闻网站表示:“这些论文提交的评审人建议中,使用了评审人的真实姓名,但假冒了其电子邮件地址。”
"The scenes in the TV adaptation are beautiful, and also consistent with the original work," a Douban user Banchengyansha said.
inspiring

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 90后买房被高房价“赶鸭子上架”
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

The two pleasure devices both made of bronze date back more than 2000 years to China's Han Dynasty (206 BC–220 AD).

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

That was a less marked jump than the 3 percentage point rise from August to September, however, suggesting recent curbs to property purchases may be having some effect.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
From the themed collection: 泉州建材联盟合奏产业强音
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

四线及以下城市居民在收入、教育、医疗、养老方面的经济压力与国家平均水平相近,而家庭和人际关系方面的压力比二三线城市大。
该调查讨论了对未来的预测:"生活成本总是变化的,来年将发生的变化已经有了迹象。"

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

爆发冲突的潜在可能性,将迫使中国和美国在不断变幻的环境中重新定义各自的角色,双方都对这种环境感到不安。美国大选期间的反华情绪将使紧张气氛加剧。亚洲国家将勾勒出这两个大国的影响力范围,但考虑到各国的利益各有不同,取决于各自的具体关切,联盟的构成也将变化。
但是随着朱迪-霍勒迪的回归和安东尼-戴维斯打出历史级别的数据,他们不会差到以至于能够得到上边提到的Fultz,Jackson之流。去年的选秀怎么就没那么好呢!
在出售给Facebook前,WhatsApp一直特别反对植入广告。该公司首席执行官让o库姆在自己桌上一直贴着联合创始人布莱恩o阿克顿留下的一张便条,随时提醒自己牢记公司的核心价值观:“不要广告!不要游戏!不要宣传噱头!”这样一来,短信应用只好想出别的创意。比如Tango就在用户的短信“收件箱”里插入广告。中国互联网巨头腾讯公司旗下的短信应用——微信,则通过游戏、贴纸(类似于表情符号)和移动购物等方式谋取赚钱之道。Kik则提供一种被一些人称为“聊天广告”的功能,用户通过它能和幽默网站Funny or Die及电影信息网站Moviefone这类品牌运营的聊天程序进行交谈。
e出,leg腿:露出大白腿………高雅的;但是靠这个优雅也是比较悲哀的一件事

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

农业原材料,特别是所谓的软性大宗商品,例如糖、咖啡和棉花,今年的表现在最佳之列。
马丁沃尔夫(Martin Wolf)

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

In this April 24, 1984, file photo, from left, Steve Jobs, chairman of Apple Computers, John Sculley, president and CEO, and Steve Wozniak, co-founder of Apple, unveil the new Apple IIc computer in San Francisco
“BlackBerry has not engaged in discussions with Samsung with respect to any possible offer to purchase BlackBerry,” the company said in a statement issued Wednesday afternoon. “BlackBerry’s policy is not to comment on rumors or speculation, and accordingly it does not intend to comment further.”

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

[k?n'denst]

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

n. 范围,行列,射程,山脉,一系列
饰演《哈利·波特》里赫敏一角的艾玛·沃特森在2015全球十大美女榜中居第五。这位英国演员、模特、社会活动积极分子在2015年“问男人”网站评选的“九十九位最杰出女性”中夺冠,并且在《时代》杂志全球最具影响力人物评选中列第26位。
Many analysts may be surprised at the suggestion that they have underplayed the Fed. The two factors most often cited in relation to EM assets these days are the Fed and China, and the risk that they will deliver a negative shock.
2016年的年度色彩与以往不同,它是两种颜色的组合:粉水晶(Rose Quartz,一种矿物粉色)和宁静蓝天(Serenity,一种淡蓝色)。在该公司的网站上,这两种颜色浑然融为一体,看不清它们的界线。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

一位来自美国佛罗里达州的少女引起了世人的惊叹,因为她长得酷肖迪士尼动画电影《冰雪奇缘》中的艾丽莎女王。
According to the institution, only women with a net worth exceeding 8 billion yuan are eligible to be selected as one of the top 50 richest women in China.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

年龄:39岁
超级大坏蛋们将受命保护人类——这就是《自杀小队》的主旨。 一个名叫“A.R.G.U.S”的政府机构招募了一些罪犯帮它执行危险任务,罪犯们将得到的报酬是减刑。这支特遣小队的成员有小丑、死亡射手、哈利·奎恩、回旋镖队长、杀人鳄以及DC漫画宇宙里的其他坏家伙。
公司:网络投票公司Everyone Counts

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

节目36 歌曲《中国范儿》,玖月奇迹
死亡可能隐藏在评论人的十大清单这一仪式之后,也包括实体媒体的死亡:清单在手机上更容易读,就算娱乐媒体的泛滥,已经令深刻的阅读近乎不可能实现。截止到年底,纽约今年一共上映了900多部电影,很多影片都在影院内匆匆来去,由于缺乏观众而被遗忘。尽管如此,这一年里,我看了几百部影片,喜欢其中的一部分;不出所料,大制片公司和独立公司都有垃圾制作,但和往常一样,也不乏有价值的作品。下面是我在2015年最喜欢的影片,以及今年的十则杂记。
Wishing you a sparkling New Year and bright happy New Year! May the season bring much pleasure to you.愿你的新年光彩夺目,愿你的新年灿烂辉煌!佳节快乐!

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Cross talk (Guo Degang and Yu Qian)
Susan Chan, head of iShares Asia-Pacific at BlackRock, says ETFs are more popular among institutional investors in the region.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
From the themed collection: 天津“不动产登记一网通”再提速
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
From the themed collection: 百强房企市场集中度继续提升
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Nineteen buildings disappeared in the space of 10 seconds after being demolished by a controlled explosion in China yesterday.
She's the perfect choice for this role, having hosted the Oscars last year, and previously hosted the Grammy Awards and the Primetime Emmys.
大众创业,万众创新

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Consider:
在那之前,她曾出演过大受欢迎的情景剧,并且也因饰演的角色而小有名气。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

特约专栏作家安东尼·盖尔恩是Paragon欧洲合作伙伴的常务董事。目前位于伦敦。
通常在垃圾桶里东西是没有价值的,不需要任何检查,但Qube试图用“世界上第一个智能垃圾桶”来改变这一现状。Qube声称可以帮助你监控你的垃圾,帮助你利用创新技术回收垃圾。
截止发稿时为止,在中国社交媒体上仍然能够找到一些被泄露的照片和视频。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

单词benefit 联想记忆:

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

中国旅游研究院国际旅游研究所(Institute of International Tourism)副所长蒋依依认为,外国游客数量下降的部分原因在于人民币的升值。
Christopher Nolan's World War II feature is probably just about the front runner for best film.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

leakage
With 10 guesses, an attacker would have a 39% chance of guessing Korean-speaking users' answers to the question "What is your city of birth?"

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 全国房产调控政策超400次
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

5. 弗莱德·赫什三人组(Fred Hersch Trio),《漂浮》(Floating), Palmetto。赫什目前的钢琴三人组由约翰·艾伯特(John Hébert)担任贝斯,埃里克·麦克菲森(Eric McPherson)担任鼓手,他们有着精确的优雅。这张专辑的结构如同一场夜间俱乐部演出,包括若干重新编配的标准曲,以及几首强劲而充满情感的原创曲,有着强大的表现力。
4.You Don't Like Most of Your Coworkers

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

芯片的零售价为150美元,但一次只能烤四寸的饼干。如果你用传统的烤箱,在烤箱烤一大批饼干,你也能在30分钟内烤完8到12块饼干,也更加便宜。
以我所有的爱心与真诚祝你及全家圣诞快乐。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: 家具卖场弊端渐显 无促销不销售
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

In the apparent belief that “lower for longer” now means “lower forever”, investors have been piling into EM assets in recent weeks.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

单词administration 联想记忆:
《癌症:众病之王》(Cancer: The Emperor of All Maladies),PBS,3月30日播出。该剧由《斯科茨伯勒:美国的悲剧》(Scottsboro: An American Tragedy)与《美莱》(My Lai)的导演巴拉克·古德曼(Barak Goodman)执导,肯·伯恩斯(Ken Burns)担任执行制作人,这部六小时的剧集是根据普利策获奖书籍、悉达多·穆克吉(Siddhartha Mukherjee)医生的《众病之王:癌症传》(The Emperor of All Maladies: A Biography of Cancer)改编的。
Her real-life sister Lexie often accompanies her dressed as Elsa's sister Princess Anna from the movie, and her best friend steps in when Lexie isn't available.
The Turkish president said Angela Merkel, the German chancellor, was “no different from the Netherlands” and urged émigré Turks not to vote for “the government and the racists” in upcoming European elections. Ms Merkel faces a tough re-election bid in September.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: 钜豪照明遭范冰冰反诉判偿40万
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

n. 隧道,地道

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

3.2 深化重要领域和关键环节改革
It’s sometimes one of the scariest words in the English language, but it’s a word you should be prepared to say when opportunities arise in your career: Yes.
While he wins the Nerb prize, the sister prize, for the best verb masquerading as a noun, is won by another consultant who referred to a “global touch-base”.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

infect+ion→传染;感化
There are 27 companies that are dropped from the list this year, including AT&T, IBM, Siemens and Xerox.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 深度贫困地区可灵活使用宅基地
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

“From one son of the South and sports fanatic to another, my hat’s off to you,” tweeted Bill Clinton, the former US president, in response to the article.
她解释说:“这一事件牵涉了许多方面,例如环境、能源、工作场所灾难和大国政府职能。它成为了人们焦虑情绪聚集的一个焦点。”

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

伦敦——自2002年开设以来,“周六人物”(Saturday Profile)便旨在向《纽约时报》的读者介绍世界各地的人。读者可能从来没有听说过这些人,但他们过着有趣的生活,做过不同寻常的事情,或者刚刚有了一段非凡的经历。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 沪指涨2.9%接近2900点 两市百股涨停
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

中国官方采购经理人指数(PMI)显示,中国制造业活动出现了3月份以来的最慢扩张速度。与此同时,汇丰银行(HSBC)发布的正式PMI指数也出现了6个月内的最低读数。
新上榜品牌有26个,其中前三名为乐视、安邦和东方财富,其中民营品牌占70%。小米品牌价值涨幅最大,其价值是去年五倍,为73亿美元,TCL和华为位居其后。
The Raptors entered February as the team that most needed to make a move: their hot start was fading, their defense wasn't up to snuff for a contender, they had a massive hole at the four, and they felt added urgency to make the most of Kyle Lowry's prime in advance of his upcoming free agency.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

小牛队老板马克-库班曾下过比这更大的赌注,但是,他尝试换来诺埃尔作为空中接力/护框型球员——像泰森-钱德勒那样,舍弃的东西并不多(贾斯廷-安德森和一次伪第一轮选秀权)。
节目1 开场曲《欢歌贺新春》,中央电视台48位主持人
智能手机巨头小米创始人雷军同意此观点,将AlphaGo的取胜描述为人工智能领域的突破。
酒店和餐饮业高管薪酬均值增速最快,均为47.58%。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

一有机会就炫一下小卷毛。
Adding to the growing literature of sell-side analysts who think the answer to Apple's (AAPL) market valuation woes (down 35% since September) is a low-cost iPhone, MorganStanley's Katy Huberty has looked at China, the world's largest smartphone market, and done the math.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

今年年底10年期美国国债收益率会突破3%吗?
il不+legal合法的→不合法的
6. Photojournalist

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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The prices are tough for ordinary Brazilians to afford. The minimum wage in the country is $330 a month, just about what Ferreira said she earns.
Haruhiko Kuroday, the Japanese central bank governor said: “I think we can be cautiously optimistic about the global outlook.

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