Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
When it’s time to buy a new car, you have 36 brands to choose from. Each automotive brand has something to offer, but not every brand is right for every buyer. Some brands excel at making performance cars, others focus on making family-friendly crossovers or specialize in luxury cars.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
《傲骨贤妻》(The Good Wife)：艾丽西娅(Alicia)的秘密暧昧对象威尔（Will，乔希·查尔斯[Josh Charles]饰）在第五季末死去，CBS频道的这部性感法庭剧似乎要完蛋了，但是第六季却似乎充满了疯狂的能量——艾丽西娅初露头角的政治竞选、新旧公司的权力之争、合伙人卡里(Cary)的棘手法律事务。艾丽西娅不再那么完美，《傲骨贤妻》因此更好看了。
*Writing for a Variety Series: “Last Week Tonight With John Oliver”
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
企业也在其他方面受益。英国国家电网公司的业务分析经理克雷格?罗拉森(Craig Rollason)表示，他通过指导一位Teach Firste人提高了自己的指导技巧。
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
As a result, 39 percent of the post-90s generation tries to avoid the negative effects of mobile phone use through measures like turning off app notifications, intentionally limiting the frequency of social media interactions and staying away from social media entirely in certain situations.
Trends and targets in antiviral phototherapy
Today's and tomorrow's technology sits on top of multiple layers, every one of which is changing and has to inter-operate with others. This makes our gadgets, the internet of things, phones and laptops unstable. And it makes consumers irritated. How many of your apps actually work--and actually make life easier, faster or more fun? I'd expect to see consumer cynicism grow, as delight is overtaken by disappointment. This will put pressure on hardware and software developers to deliver that most boring of qualities: reliability.
菲律宾参议院一委员会就国内发生的法外处决事件举行了听证会，罗纳德?德拉罗萨(Ronald Dela Rosa)在会上表示，自7月1日杜特尔特就任总统后，有712人在警方缉毒行动中被杀，还有1067起死亡正被作为与毒品相关的自告奋勇者杀人案件在调查中。
No.4: The 1st Useful Mechanical Pet
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Over at Huffington Post Mark Gongloff warns: That 'dramatic downgrade of U.S. economic growth in the first quarter revealed the economy's lingering weakness, exposed the folly of Washington's austerity obsession and slapped the Federal Reserve's newfound optimism right in the face.' And with politics deteriorating, it'll get worse.
Novel biosensing methodologies for ultrasensitive detection of viruses
On Turkey, which recently shot down a Russian warplane, Putin said he sees no possibility of overcoming the strained ties with the current Turkish leadership. He said he was shocked to see that Turkey hadn't tried to explain its action but turned to help from NATO instead.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
They are typically designed for students with an average age of 22.
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
Against: Although it picked up a best editing prize from the LA Film Critics Association, it was ignored by their New York counterparts. Could its momentum be waning
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
For parents, it is always a struggle to carry their children all day long, especially when they’re getting bigger and heavier.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
The contiguous United States set a temperature record in 2012, a year of scorching heat waves and drought. But, mostly because of the unusual chill in the East, 2014 was only the 34th warmest year on record for the lower 48 states.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Consumers in many parts of the world have a preference for buying local which has helped boost the value of local brands.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Best Companies rank: 59
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
For the fourth year in a row, the top five places continue to be dominated by the same five intercontinental EMBAs. Tiemba came top this year not by spectacularly outperforming its rivals but thanks to a strong performance across most indicators. In particular, the alumni have the second highest salary on average ($324,000) behind alumni from the Kellogg/HKUST programme ($408,000). Tiemba is also ranked second for career progression and fourth for work experience.
Antiviral drug discovery: broad-spectrum drugs from nature
“I am proud of my position as a boss, as a person that runs my own company,” Perry told FORBES for our Celebrity 100 cover story this past summer. “I’m an entrepreneur. … I don’t want to shy away from it. I actually want to kind of grab it by its b---s.”
In month-on-month terms, consumer prices fell 0.1 per cent after having risen 0.7 per cent a month earlier.
Influenza neuraminidase: A druggable target for natural products
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
'A little bit in shock,' said director Steve McQueen, before shrugging 'Roll, Jordan, roll'-the lyrics to the old gospel song sung in the slavery epic.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Despite the reported success of the Duke and Duchess of Cambridge's official visit to Canada back in September, timekeeping needs to be looked at for future trips.
Faster progress in work to improve environment, particularly air quality, is what people are desperately hoping for, and is critical to sustainable development. We must adopt well-designed policies, tackle both symptoms and root causes, and take tough steps to make the grade in responding to the people.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
During your early years wasthere anything that inspired or sparked your imagination to start writing theway that you have done so far?
For Maddie Ziegler, from Pennsylvania, life couldn't be more different.
Ohsumi’s research on autophagy shines a light on ubiquitous diseases such as Parkinson’s and diabetes.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
6. Make a plan.
Inhibition of SARS coronavirus helicase by bismuth complexes
Global gold production rose to 3,268.7 tonnes in 2017 from 3,263 tonnes a year earlier, according to the WGC. That was the smallest increase since 2008, when gold mined fell more than 2 per cent during the financial crisis.
As a national exam with more than 1 million test takers every year, the National Postgraduates Entrance Examination is very important for students' academic life, and cheating incidents have been exposed from time to time.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Managers are able to reward their subordinates in unique, personalized ways thanks to the budget they receive from corporate. Two examples of past bonuses: free trail rides at an equestrian stadium and a barbeque with lassoing and horseshow throwing lessons.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
"The scenes in the TV adaptation are beautiful, and also consistent with the original work," a Douban user Banchengyansha said.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
The two pleasure devices both made of bronze date back more than 2000 years to China's Han Dynasty (206 BC–220 AD).
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
That was a less marked jump than the 3 percentage point rise from August to September, however, suggesting recent curbs to property purchases may be having some effect.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
在出售给Facebook前，WhatsApp一直特别反对植入广告。该公司首席执行官让o库姆在自己桌上一直贴着联合创始人布莱恩o阿克顿留下的一张便条，随时提醒自己牢记公司的核心价值观：“不要广告！不要游戏！不要宣传噱头！”这样一来，短信应用只好想出别的创意。比如Tango就在用户的短信“收件箱”里插入广告。中国互联网巨头腾讯公司旗下的短信应用——微信，则通过游戏、贴纸（类似于表情符号）和移动购物等方式谋取赚钱之道。Kik则提供一种被一些人称为“聊天广告”的功能，用户通过它能和幽默网站Funny or Die及电影信息网站Moviefone这类品牌运营的聊天程序进行交谈。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
In this April 24, 1984, file photo, from left, Steve Jobs, chairman of Apple Computers, John Sculley, president and CEO, and Steve Wozniak, co-founder of Apple, unveil the new Apple IIc computer in San Francisco
“BlackBerry has not engaged in discussions with Samsung with respect to any possible offer to purchase BlackBerry,” the company said in a statement issued Wednesday afternoon. “BlackBerry’s policy is not to comment on rumors or speculation, and accordingly it does not intend to comment further.”
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Many analysts may be surprised at the suggestion that they have underplayed the Fed. The two factors most often cited in relation to EM assets these days are the Fed and China, and the risk that they will deliver a negative shock.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
According to the institution, only women with a net worth exceeding 8 billion yuan are eligible to be selected as one of the top 50 richest women in China.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Wishing you a sparkling New Year and bright happy New Year! May the season bring much pleasure to you.愿你的新年光彩夺目，愿你的新年灿烂辉煌！佳节快乐！
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Cross talk (Guo Degang and Yu Qian)
Susan Chan, head of iShares Asia-Pacific at BlackRock, says ETFs are more popular among institutional investors in the region.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Nineteen buildings disappeared in the space of 10 seconds after being demolished by a controlled explosion in China yesterday.
She's the perfect choice for this role, having hosted the Oscars last year, and previously hosted the Grammy Awards and the Primetime Emmys.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
中国旅游研究院国际旅游研究所(Institute of International Tourism)副所长蒋依依认为，外国游客数量下降的部分原因在于人民币的升值。
Christopher Nolan's World War II feature is probably just about the front runner for best film.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
With 10 guesses, an attacker would have a 39% chance of guessing Korean-speaking users' answers to the question "What is your city of birth?"
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
5. 弗莱德·赫什三人组(Fred Hersch Trio)，《漂浮》(Floating)， Palmetto。赫什目前的钢琴三人组由约翰·艾伯特(John Hébert)担任贝斯，埃里克·麦克菲森(Eric McPherson)担任鼓手，他们有着精确的优雅。这张专辑的结构如同一场夜间俱乐部演出，包括若干重新编配的标准曲，以及几首强劲而充满情感的原创曲，有着强大的表现力。
4.You Don't Like Most of Your Coworkers
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
In the apparent belief that “lower for longer” now means “lower forever”, investors have been piling into EM assets in recent weeks.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
《癌症：众病之王》(Cancer: The Emperor of All Maladies)，PBS，3月30日播出。该剧由《斯科茨伯勒：美国的悲剧》(Scottsboro: An American Tragedy)与《美莱》(My Lai)的导演巴拉克·古德曼(Barak Goodman)执导，肯·伯恩斯(Ken Burns)担任执行制作人，这部六小时的剧集是根据普利策获奖书籍、悉达多·穆克吉(Siddhartha Mukherjee)医生的《众病之王：癌症传》(The Emperor of All Maladies: A Biography of Cancer)改编的。
Her real-life sister Lexie often accompanies her dressed as Elsa's sister Princess Anna from the movie, and her best friend steps in when Lexie isn't available.
The Turkish president said Angela Merkel, the German chancellor, was “no different from the Netherlands” and urged émigré Turks not to vote for “the government and the racists” in upcoming European elections. Ms Merkel faces a tough re-election bid in September.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
It’s sometimes one of the scariest words in the English language, but it’s a word you should be prepared to say when opportunities arise in your career: Yes.
While he wins the Nerb prize, the sister prize, for the best verb masquerading as a noun, is won by another consultant who referred to a “global touch-base”.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
There are 27 companies that are dropped from the list this year, including AT&T, IBM, Siemens and Xerox.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
“From one son of the South and sports fanatic to another, my hat’s off to you,” tweeted Bill Clinton, the former US president, in response to the article.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
The Raptors entered February as the team that most needed to make a move: their hot start was fading, their defense wasn't up to snuff for a contender, they had a massive hole at the four, and they felt added urgency to make the most of Kyle Lowry's prime in advance of his upcoming free agency.
Length-scale dependence of protein hydration-shell density
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Adding to the growing literature of sell-side analysts who think the answer to Apple's (AAPL) market valuation woes (down 35% since September) is a low-cost iPhone, MorganStanley's Katy Huberty has looked at China, the world's largest smartphone market, and done the math.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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The prices are tough for ordinary Brazilians to afford. The minimum wage in the country is $330 a month, just about what Ferreira said she earns.
Haruhiko Kuroday, the Japanese central bank governor said: “I think we can be cautiously optimistic about the global outlook.